To the Editor: Theo G.M. van Erp, M.A., and co-workers (1) presented interesting data that link fetal hypoxia to smaller hippocampal volume and subsequent greater risk of schizophrenia. Commenting on their results, the authors asserted that the differences they found between patients’ hippocampal measures and those observed in unaffected siblings and unrelated comparison subjects were unlikely to be a consequence of the larger magnitude of the hypoxic event among probands than among healthy comparison subjects. However, analysis of the obstetric histories of schizophrenic patients’ mothers has often revealed a significantly higher risk of unfavorable pregnancy outcome (2, 3). Among schizophrenic patients’ mothers, pregnancies end with miscarriage or preterm birth more often than among comparison subjects (4). It is therefore reasonable to suppose that the mothers of schizophrenic patients are, in general, at greater risk of suffering from obstetric complications, which might determine the death of the fetus or the birth of brain-damaged offspring.