Keeping up with certain aspects of general medicine is an absolute necessity for the competent practice of psychiatry. It is also increasingly hard to do. For those individuals, like myself, who have not been able to stay current with all of their back issues of the New England Journal of Medicine,Annals of Internal Medicine,JAMA, and the Lancet, APA’s Review of Psychiatry series offers a readable update that covers a handful of interesting topics. Cutting-Edge Medicine is number 21 in this series, and Nada Stotland, the volume editor, has pulled together four loosely affiliated but nicely written chapters summarizing pertinent subjects in general medicine likely to be of particular interest and importance to practicing psychiatrists. These chapters deal with cardiology, gastrointestinal diseases and disorders, solid organ transplantation medicine, and psychiatric disorders of the menstrual cycle.