The "decade of the brain" crowned the belief that natural science offers the best approach to understanding human behavior. But how valid is the "hard" science that purports to close the mind-brain gap? In a recent issue of the Journal, Leuchter et al. (2), using quantitative electroencephalography (QEEG), found—contrary to the study by Dr. Mayberg et al.—that "placebo treatment induces changes in brain function that are distinct from those associated with antidepressant medication" (p. 122). As happens often in biological psychiatry, two studies purporting to measure the same phenomenon came to opposite conclusions. The authors of the QEEG article did, however, acknowledge that "these data do not prove a causal link between brain functional changes and the therapeutic effect of either medication or placebo" (p. 128).