To the Editor: We commend Ann A. Hohmann, Ph.D., M.P.H., and M. Katherine Shear, M.D. (1), on their attention to important issues in translating efficacy research to real-life research in the community. We are completing a trial of community-based support-education groups for single mothers (2), a population facing high poverty rates and an elevated risk of mental health problems, particularly depression. We considered similar issues before our trial. For example, we undertook feasibility work to determine appropriate identification and enlistment of study participants, adequate retention in groups, and acceptability and completion of evaluations. We contemplated the generalizability of the study setting, the similarity of the participants to those most in need, and the relevance of the outcome goals to the participants.