Received Sept. 27, 2001; revision received July 2, 2002; accepted July 8, 2002. From the Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig-Maximilian University; the Molecular Geriatrics Corporation, Vernon Hills, Ill.; the Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Japan; the Department of Neuroscience and Neurology, University Hospital, University of Kuopio, Kuopio, Finland; and the Brain Physiology and Metabolism Section, National Institute on Aging, NIH, Bethesda, Md. Address reprint requests to Dr. Buerger, Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig-Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany; katharina. email@example.com (e-mail).Supported by grants from the Volkswagen Foundation (Dr. Hampel), Hirnliga (Drs. Hampel and Buerger), and the Foerderprogramm fuer Forschung und Lehre, Faculty of Medicine, Ludwig-Maximilian University (Drs. Buerger, Teipel, and Hampel).The authors thank F. Jancu, B. Riemenschneider, J. Wagner, and O. Pogarell, M.D., for clinical support, T. Nolde, H. Gluba, and H. Ott for technical assistance, and A.L.W. Bokde, Ph.D., for review of the article.