In the National Population Health Survey, of 668 subjects with an episode of major depression (in the preceding year), 194 reported antidepressant use, compared to 482 of 14,108 subjects without a major depressive episode. As expected, the rate of use was much higher in those with a depressive episode, but the fact remains that over 70% of those taking antidepressants had no episodes of major depression in the preceding year. A proportion of these subjects may derive from the 15%–20% of the population with lifetime major depression (3), some of whom have successfully achieved control of their depressive disorders by using antidepressant medications. Such success is not reflected in the 27.1% use rate reported. To illustrate this point, suppose that 10 of 50 persons with active major depression are found to be taking antidepressants in a survey with a group size of 1,000. The estimation approach of Dr. Laukkala et al. would put the use rate at 20%. However, if another 50 of the remaining 950 members of the population (who were not depressed in the last year) had recurrent major depression that is successfully controlled by medications, then an alternative way of depicting use would be to estimate it at 60 of 100, or 60%.