The sections of the book are well organized and demonstrate a well-thought-out approach to this multifaceted illness. The description of symptoms is excellent and quite clear. The discussion of neurodevelopmental risks is a good addition to this book. The association of the risk factors is, however, left unclear. A detailed review of exposure and outcome in an odds ratio format would have been a helpful contribution. The author covers genetics reasonably well, although more space could be given to Meehl’s concept of schizotaxia and the important implications of this concept. The genetics section is also very limited in scope, possibly an artifact of being a generally brief text, but there is a wealth of evidence supporting a genetic transmission for many cases of schizophrenia. A very interesting discussion of neurocognitive deficits follows the genetics section and includes an interesting clinical vignette. The chapter on neuroimaging is composed of odd combinations of material. The information is factually correct but seems uneven. For example, I found it odd that that the author mentions historical footnotes like pneumoencephalograms while virtually ignoring the single photon emission tomography literature. The discussion of treatment is well balanced and avoids the trap of condemning early practitioners’ attempts and failures in the care of this enigmatic psychosis.