The book is not meant to be an exhaustive treatment of every aspect of this subject but seems to have selected particular areas likely to be of interest to clinicians. The chapter on depression in women contains two very useful tables that compile information on the teratogenicity of relevant psychotropics and a timely, evidence-based discussion about the relative value of estrogen treatment for postmenopausal depression (it is probably effective for some but should not supplant initial pursuit of better-studied modalities). Similarly, the chapter "Chronic and Recurrent Depression" tells a story, rather than offering an exhaustive review, with a focus on key studies over the past two decades that established the value-added effect of psychotherapy, but suggests this may be true only if it is administered with sufficient frequency and intensity. The chapter on bipolar illness focuses on interepisode management, providing advice about frequency of visits, family involvement, the destabilizing effects of inadequate sleep and light exposure, and the importance of the therapeutic relationship, especially for the prevention of the manic phase. Finally, the chapter on "minimally invasive brain stimulation" modalities largely focuses on repetitive transcranial magnetic stimulation and vagal nerve stimulation, providing a cautious, sober assessment of the limited knowledge in this area. The authors’ caution about the need to limit enthusiasm for vagal nerve stimulation until it is tested in controlled studies is particularly timely in the light of recent news that the first controlled trial for this treatment was negative, casting some doubt on the open trials reported in this chapter, although the length of this trial may have been too short to measure delayed effects.