To the Editor: Schizophrenic patients have a higher risk of cardiovascular mortality than healthy individuals, possibly because of excessive smoking, the schizophrenic psychosis itself, or a combination of both factors. Of interest, the risk of sudden cardiac death for individuals receiving antipsychotic drugs is about 2.4 times greater than that for nonusers (1). The reason for this awaits a definitive explanation. A recent review by Drs. Glassman and Bigger focused on the relationship between prolongation of the QTc interval induced by a neuroleptic and the probability of the occurrence of sudden cardiac death. It was found that various antipsychotic drugs prolong mean QTc intervals differently; for phenothiazines (e.g., thioridazine), this effect is particularly strong and appears to be clinically relevant. However, not all drugs that prolong QTc intervals also produce torsade de pointes and sudden cardiac death. For this reason, neuroleptic-induced prolongation of QTc intervals can only be considered a warning for the possibility of torsade de pointes and sudden death and not a definitive indicator for the risk itself.