To my knowledge, this is the second reported case of ziprasidone overdose in the literature. As in the previous case (3), only minimal QTc change was noted. In addition, this patient experienced borderline intraventricular conduction delay, delirium, hemodynamic instability, diarrhea, and urinary retention. It is difficult to know to what extent the ziprasidone overdose was related to her clinical course. She sought medical help quickly, perhaps influencing the amount of ziprasidone that was absorbed. Multiple medical conditions were present that could have influenced her clinical course. These included her altered physical and mental status, concomitant medication use, obesity, diabetes, and hypercholesterolemia.