I call attention to radical contemporary ontological approaches that begin to offer some hope of progress. These concern three related assumptions: one concerning the nature of inanimate matter, the Cartesian bifurcation into an inner and outer world, and the so-called "referential-instrumental" conception of language. While these assumptions may be acceptable and useful in many contexts and applications, strong arguments have been made to show that they are inadequate when it comes to psychiatric and psychological matters. Typically, these arguments are ignored or brushed aside.