Posttraumatic stress disorder (PTSD) is one of the most prevalent, disabling, and costly as well as the least understood of the anxiety disorders. Despite a century-old interest in the psychological and behavioral effects of trauma, systematic empirical research in this area is little more than a decade old. Responding to the recent upsurge of interest in this disorder on the part of clinicians and researchers alike, the editors of this volume seek to provide “mental-health professionals” with a comprehensive overview of PTSD from multiple perspectives that is “readable, informative and clinically helpful.” They have selected a format that is strongly evidence-based, scholarly, and yet not too detailed or exhaustive, allowing the interested reader and clinician to grasp key issues in epidemiology, diagnosis, pathophysiology, and treatment through highly readable, relatively brief (15–20 pages), modestly referenced (often fewer than 50 references), yet fairly comprehensive reviews of key areas. The text is somewhat slanted toward the relatively recent appreciation of the biological basis of the disorder, which has replaced older, predominantly psychological paradigms and made this disorder one of the most interesting opportunities to study the convergence of environmental events and genetic/neurodevelopmental/biological predisposition. Throughout the book, there is a refreshing acknowledgment of the limitations of our current understanding, even as the excitement of discovery in this new area continues.