Dr. Weissman, one of the world’s leading researchers in depression, was President of the American Psychopathological Association at its 89th meeting and served as editor of this excellent compilation of papers presented at that meeting. The book surveys past research accomplishments, looks ahead to new research directions, and concludes with a review of current biological and psychotherapeutic treatment strategies. The chapters reviewing the past accomplishments and future directions provide a superb overview and summary for the researcher and clinical scholar in the field of depression. For example, David Healy reviews the past development of antidepressant drugs and then looks ahead to new genetic and neuroimaging techniques that are increasingly guiding the development of antidepressant drugs. In a complementary chapter, Robert Michels surveys the changes over the past three decades in diagnosis, clinical understanding, and health care delivery for the treatment of depression.