We do not suggest that 5-HT2 receptors make no contribution to the overall picture of atypicality. We propose that 5-HT2 receptors are not necessary for atypicality, as shown by studies of amisulpride, remoxipride, and now aripiprazole, and that they are not sufficient for atypicality, as shown by studies of MDL-100907 and fananserin. Even in drugs with mixed 5-HT2 and D2 action, D2 receptor affinity is the biggest factor for atypicality. In fact, Meltzer et al. (3) stated, "The low D2 affinity values of atypical drugs contribute more than their high 5-HT2 affinity values" (emphasis added); 64% of the typical-atypical difference, as revealed by discriminate function analysis, was accounted for by low affinity at the D2 receptor, and only 17% was accounted for by the addition of 5-HT2 receptor affinity (3).