I also reviewed the medical literature (MEDLINE, from January 1996 to April 1999) for references to the lesser-known substances discussed at Internet drug information sites. Most of the reports dealt with acute medical problems related to substance use, although a few dealt with long-term misuse. I found no reports of problems involving any of the lesser-known hallucinogens discussed by Drs. Halpern and Pope, although one article discussed the potential for interactions between ayahuasca and selective serotonin reuptake inhibitors. In contrast, there were seven reports dealing with use of GHB, five on dextromethorphan, five on various anticholinergic nightshade species, five regarding nutmeg, three on kava-kava, and one each regarding ketamine, dimenhydrinate, diphenhydramine, 2-CB (a synthetic serotonergic hallucinogen), and absinthe.