First, the authors stated that deficits in olfactory identification are not consistently seen in patients with Huntington’s disease. In fact, olfactory loss is common in patients with Huntington’s disease once the clinical signs of the disorder are manifest. For example, in one study (2), 25 of 25 Huntington’s disease patients exhibited Pennsylvania Smell Identification Test scores below those of matched comparison subjects and at-risk asymptomatic relatives. This is nearly equivalent to the finding reported by my colleagues and me in 1987 (3) that 23 of 25 patients with early-stage Alzheimer’s disease who were capable of psychophysical testing scored below matched normal comparison subjects on the Pennsylvania Smell Identification Test. In accordance with the general thesis of Dr. Devanand et al., we found in this early study that only two of 34 patients with Alzheimer’s disease were aware of their deficit.