Robert Burton (1577–1640) wrote in his book The Anatomy of Melancholy that the "inbred cause of melancholy is our temperature, in whole or part, which we receive from our parents" and "such as the temperature of the father is, such is the son’s, and look what disease the father had when he begot him, his son will have after him" (3). Burton continued, "I need not therefore to make any doubt of melancholy, but that it is an hereditary disease." Garrison (4) noted that "In the Historiettes of Tallemant des Réaux,there are many amusing details about the delusions, obsessions, phobias, fetishisms, and introversions of the nobles, with genealogic tables, signalizing morbid heredity." Gédéon Tallemant des Réaux (1619–1692) was a French writer. His Historiettes is a series of brief anecdotal portraits of persons prominent in the Paris of his day. Phillippe Pinel (1745–1826), one of the founders of modern psychiatry, was accepted in his own day as an outstanding physician (5). Pinel wrote many pages about heredity. In his book on heredity, Pinel said, "It would be difficult not to concede a hereditary transmission of mania, when one recalls that everywhere some members of certain families are struck in several successive generations" (5).