To the Editor: I read with great interest the serendipitously juxtaposed articles by Daniel N. Klein, Ph.D., et al. (1) and Ernst R. Berndt, Ph.D., et.al. (2). The article by Dr. Klein et al. described an elegantly performed 5-year study of the course and outcome of dysthymic disorder, whereas the article by Dr. Berndt et al. addressed the loss in personal achievement and actualization among patients with chronic depression. Clearly, the cost in human suffering and compromised development as a result of these mood disorders is profound and has heretofore been underappreciated.