To the Editor: It was dismaying to read the article by Jerome H. Markovitz, M.D., M.P.H., et al. (1) concerning platelet function in depressed subjects before and after sertraline treatment. First, the statistical analyses of the data were faulty. Because of the performance of multiple t tests, the experiment-wise alpha should have been adjusted to a more stringent level. By use of the common Bonferroni method (2), the 0.05 alpha would have been divided by the number of t tests performed. If the data had been analyzed correctly, there would have been no significant differences between depressed and comparison subjects, or in depressed patients before and after sertraline treatment, in the parameter of in vitro collagen-induced platelet activation. In addition, the authors went beyond their data by stating in their discussion that "depressed patients with a family history of coronary heart disease may have increased fibrinogen receptor binding, although the findings were not statistically significant due to the small number of subjects" (p. 1007). In fact, the difference was not statistically significant—period!