Other dermatologic adverse effects, including pruritus, rash (mainly urticarial), and ecchymosis, among others, have been reported with paroxetine (4). However, to our knowledge, this is the first report of cutaneous vasculitis induced by paroxetine. The reemergence of the problem during another trial with the drug strongly supports the association between the two. Paroxetine’s high-affinity binding to human platelet membranes (5) and serotonin’s ability to induce and augment platelet aggregation (6) may explain this reaction. Physicians should be alert to this potential serious complication with antidepressant medications, including paroxetine.