Compared with functional MRI (fMRI), the use of structural neuroimaging techniques such as VBM eliminates the dependence on performance of a functional task inside the MRI scanner and provides anatomical information that is potentially more stable and more closely related to disease traits. Gray matter volume can change for many reasons. Increases or decreases can reflect developmental changes or the effects of use and disuse of a brain structure. The implication of this study is that gray matter volume is related to the amount of mental processing devoted to the task of that brain region. The combination of VBM with taste- and reward-related measures in this investigation corroborated the specificity of the findings and is a major strength of the study. Previous research with structural neuroimaging in anorexia and bulimia nervosa has shown poor consistency of results across studies (6). The investigation by Frank et al. represents a significant contribution to the field, providing a different picture from the existing data, which suggest regional reductions rather than increases in gray matter volume in anorexia nervosa. Notably, it is the largest neuroanatomical study in eating disorders to date, and it includes key methodological improvements. To overcome the sensitivity of VBM to hydration status (7), Frank et al. strictly controlled food and fluid intake in the participants with anorexia and bulimia nervosa for 7–10 days before scanning sessions, as part of inpatient or partial hospital treatment. In addition, the authors used the most robust methodology for VBM analysis, with an algorithm to improve image registration (diffeomorphic anatomical registration through exponentiated Lie algebra—DARTEL) (8). They also controlled for the effect of a number of confounding variables, such as medication use. Altogether, the study adhered to high methodological standards that support the validity of the findings.