Received Aug. 18, 1999; revisions received Feb. 8, March 31, and Sept. 19, 2000; accepted Oct. 4, 2000. From the Laboratory of Depression and Medical Comorbidity, Program in Geriatrics and Neuropsychiatry, Department of Psychiatry, and the Department of Biostatistics, University of Rochester School of Medicine and Dentistry. Address reprint requests to Dr. Lyness, Department of Psychiatry, University of Rochester Medical Center, 300 Crittenden Blvd., Rochester, NY 14642; email@example.com (e-mail). Supported in part by NIMH grants MH-01113 (Dr. Lyness) and MH-18911 (Dr. Caine). The authors thank T.K. Noel, C. Doane, A. Wisner, A. Gleason, G. Kiernan, H. Stiner, and Z. Yoediono; the patients and staff of the offices of Drs. J. Allen, M. Bergin, M. Berliant, C. Conners, R. Greene, M. Labanowski, R. Maggio, B. Peyser, and R. Pincus; and the Family Medicine Center at Highland Hospital, Rochester, N.Y.