To the Editor: We would like to thank Drs. Schneier, Liebowitz, and Laruelle for their comments regarding our article, which described the association between low dopamine transporter binding and detached personality. Indeed, it may be difficult to discern the psychological basis for avoidant behavior with a self-rating instrument such as the Karolinska Scales of Personality. Patients with either social phobia or schizoid personality disorder do experience discomfort when interacting socially, although this is because of anxiety (often in the presence of a desire to socialize) in the former and more because of a lack of interest in the latter. Although many of the detachment items in the Karolinska Scales of Personality do reflect more aloofness than phobic anxiety about socialization (e.g., "I am [not] deeply moved by other people’s misfortunes," "I [do not] want to confide in someone, when I am worried and unhappy"), we agree that the association between detached behavior and low dopaminergic transmission reported by us and others (Farde et al., 1997; Breier et al., 1998) may relate to similar findings on social phobia (Tiihonen et al., 1997; Schneier et al., 2000). However, we also reported a strong positive correlation between scores on the social desirability subscale of the Karolinska Scales of Personality and dopamine transporter binding, which suggests also that motivational aspects of social behavior play a part in the described phenomenon. It is also worth noting that up to 60% of patients with social phobia also fulfill the DSM-IV criteria for avoidant personality disorder (1). This has not been fully addressed in previous studies examining dopaminergic neurotransmission in social phobia (Tiihonen et al. 1997; Schneier et al., 2000).