0
Get Alert
Please Wait... Processing your request... Please Wait.
You must sign in to sign-up for alerts.

Please confirm that your email address is correct, so you can successfully receive this alert.

1
Letter to the Editor   |    
Dr. Turecki and Colleagues Reply
GUSTAVO TURECKI, M.D., PH.D.; RICHARD BRIÈRE, PH.D.; KAREN DEWAR, PH.D.; ALAIN D. LESAGE, M.D.; MONIQUE SÉGUIN, PH.D.; NADIA CHAWKY, M.SC.; CLAUDE VANIER, M.D.; MARTIN ALDA, M.D.; RIDHA JOOBER, M.D.; CHAWKI BENKELFAT, M.D.; GUY A. ROULEAU, M.D., PH.D.
Am J Psychiatry 2001;158:148-148. doi:10.1176/appi.ajp.158.1.148

To the Editor: Drs. Hrdina and Du report the results they observed in a study (unpublished) in which they attempted to replicate our findings. In observing 17 depressed suicide subjects and 35 comparison subjects, they failed to find a relationship between variation at the T102C 5-HTR2A polymorphism and 5-HTR2A binding. As previously discussed (1), a possible explanation for this inconsistency may be related to the characteristics of the subjects included in our study, who were of French Canadian descent. This is a relatively young and isolated population that has a large background linkage disequilibrium (2). Thus, it is possible that a functional genetic variant located in a different coding or regulatory region of the 5-HTR2A gene, rather than the T102C silent polymorphism, may in fact be responsible for our positive results.

This may not have been the case in the study by Drs. Hrdina and Du because they investigated subjects of Hungarian origin. Although they did not provide details about the specific ethnic composition of their study group, the Hungarian general population is composed of several different ethnic groups with admixture among most of them. The population is not known to have undergone any event leading to the presence of the relatively large linkage disequilibrium that may be observed in subjects chosen at random (3, 4).

An additional point relates to ascertainment differences between the studies. Drs. Hrdina and Du have focused their attention on depressed suicide victims (Du et al., 1999). Our findings are not related to the phenotype, but rather to a relationship between genetic variation and 5-HTR2A binding. However, if there is less variation among binding levels in depressed patients, this group may have lower power to detect a positive association.

Turecki G, Brière R, Dewar K, Lesage A, Séguin M, Chawky N, Vanier C, Alda M, Joober R, Benkelfat C, Rouleau GA: Dr. Turecki and colleagues reply. Am J Psychiatry 2000; 157:1710–  1711
 
Brais B, Bouchard JP, Xie YG, Rochefort DL, Chretien N, Tome FM, Lafreniere RG, Rommens JM, Uyama E, Nohira O, Blumen S, Korczyn AD, Heutink P, Mathieu J, Duranceau A, Codere F, Fardeau M, Rouleau GA: Short GCG expansions in the PABP2 gene cause oculopharyngeal muscular dystrophy. Nat Genet  1998; 18:164–167; erratum, 19:404
[PubMed]
[CrossRef]
 
Goedde HW, Benkmann HG, Kriese L, Bogdanski P, Czeizel A, Beres J: Genetic markers among three population groups of Hungary. Gene Geogr  1987; 1:109–120
[PubMed]
 
Guglielmino CR, Beres J: Genetic structure in relation to the history of Hungarian ethnic groups. Hum Biol  1996; 68:335–355
[PubMed]
 
+

References

Turecki G, Brière R, Dewar K, Lesage A, Séguin M, Chawky N, Vanier C, Alda M, Joober R, Benkelfat C, Rouleau GA: Dr. Turecki and colleagues reply. Am J Psychiatry 2000; 157:1710–  1711
 
Brais B, Bouchard JP, Xie YG, Rochefort DL, Chretien N, Tome FM, Lafreniere RG, Rommens JM, Uyama E, Nohira O, Blumen S, Korczyn AD, Heutink P, Mathieu J, Duranceau A, Codere F, Fardeau M, Rouleau GA: Short GCG expansions in the PABP2 gene cause oculopharyngeal muscular dystrophy. Nat Genet  1998; 18:164–167; erratum, 19:404
[PubMed]
[CrossRef]
 
Goedde HW, Benkmann HG, Kriese L, Bogdanski P, Czeizel A, Beres J: Genetic markers among three population groups of Hungary. Gene Geogr  1987; 1:109–120
[PubMed]
 
Guglielmino CR, Beres J: Genetic structure in relation to the history of Hungarian ethnic groups. Hum Biol  1996; 68:335–355
[PubMed]
 
+
+

CME Activity

There is currently no quiz available for this resource. Please click here to go to the CME page to find another.
Submit a Comments
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discertion of APA editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe



Related Content
Books
The American Psychiatric Publishing Textbook of Psychopharmacology, 4th Edition > Chapter 3.  >
The American Psychiatric Publishing Textbook of Psychopharmacology, 4th Edition > Chapter 3.  >
The American Psychiatric Publishing Textbook of Substance Abuse Treatment, 4th Edition > Chapter 2.  >
Dulcan's Textbook of Child and Adolescent Psychiatry > Chapter 38.  >
Dulcan's Textbook of Child and Adolescent Psychiatry > Chapter 38.  >
Topic Collections
Psychiatric News
APA Guidelines