The main interest of this book stems from the four chapters focusing on the pathophysiology of schizophrenia. Although these insightful chapters emphasize very different methodologies and/or brain systems, they share a common perspective on the heterogeneity of schizophrenia. Indeed, they posit that schizophrenia is not a unitary disorder but, rather, includes distinct dimensional clinical phenotypes. In addition, these chapters posit that the dimensional phenotypes reflect dynamic dysfunctions on specific neural circuits, as opposed to a narrow-minded "localizationist" perspective. Two of these four chapters may be among the best efforts ever at integrating clinical symptoms and pathophysiology; reading these two chapters may be demanding for nonexperts but is definitely worth the extra effort.