The recently published practice parameters of the American Academy of Child and Adolescent Psychiatry (7) and, of course, DSM-IV include physical and laboratory examination as required in making a diagnosis. However, how many child psychiatrists actually incorporate a physical examination in a meaningful way? There has been a trickle-down effect of adult biological psychiatric practice on child psychiatry as the biological revolution has made it more obvious than ever that the major mental illnesses of childhood are based in neurotransmitter dysfunction, genetics, and anatomy. As psychopharmacology has been extended to childhood, it has become mandatory to consider the entire biological basis of behavior in pediatric psychiatric diagnosis, which, in the past, had been more or less limited to psychodynamic formulations, often based on Freudian developmental theory or what might have been referred to as behavioral or developmental pediatrics.