Abnormalities may be found from magnetic resonance imaging (in a minority of cases), EEG, electromyogram, and CSF studies and serum tests for the anti-Hu antibody (3). (Since the submission of my original letter, several other antineuronal antibodies have been identified, and they are described in the second 2000 edition of Neurobase.) Syndromic presentation should prompt a workup for malignancy. Treatment should be directed at any underlying malignancy, seizures, or psychiatric symptoms. Also, some patients, particularly those with limbic encephalitis, may benefit from steroids, plasmapheresis, or intravenous immunoglobulin.