Acupuncture, initially developed in Chinese medicine in the fifth century B.C., has been increasingly applied to the alleviation of pain, particularly in the presence of cancer (1, 2). Serotonergic pathways have been implicated in pain relief, and they have been useful in relieving discomfort in both fibromyalgia and neuropathy (3, 4). Thus, it was hypothesized that acupuncture might work synergistically with serotonergic therapy for pain relief in neuropathy. Here, three cases show the possible synergism of serotonin (5-HT) effects induced by nefazodone with acupuncture. Each patient underwent six acupuncture treatments, two at each visit. Baseline platelet 5-HT content was measured once at baseline, once after 8 weeks, and three times during the acupuncture series. The patients were not specifically followed beyond the course of the acupuncture treatments.