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Letter to the Editor   |    
Quetiapine for Treatment-Resistant Mania
EDUARDO DUNAYEVICH, M.D.; STEPHEN M. STRAKOWSKI, M.D.
Am J Psychiatry 2000;157:1341-1341. doi:10.1176/appi.ajp.157.8.1341

Antipsychotic medication is safe and effective in the treatment of mania (1). When compared to conventional antipsychotics, atypical antipsychotics carry a lower risk of extrapyramidal side effects and tardive dyskinesia (2). Some of these agents appear efficacious in the treatment of mania (35). Quetiapine is an atypical antipsychotic that is effective for the treatment of schizophrenia (6). However, to our knowledge, there are no published reports of quetiapine used in the treatment of bipolar disorder. We report the use of quetiapine as an adjunctive therapy in combating treatment-resistant bipolar disorder.

Ms. A was a 39-year-old married woman who was hospitalized for worsening mania after reduction of her trifluoperazine dose from 15 to 12 mg/day. Her symptoms included insomnia, racing thoughts, sexual preoccupation, impulsivity, irritability, increased energy, pressured speech, flights of ideas, paranoid ideation, auditory hallucinations, and suicidal ideation. She was also taking valproic acid, 2000 mg/day, and lithium carbonate, 1200 mg/day. Her blood levels of these drugs were 116 mg/ml and 1.2 meq/ml, respectively. Ms. A’s bipolar disorder had begun during her 20s, and she had initially responded to treatment with lithium carbonate. After several relapses, she started experiencing breakthrough symptoms while taking therapeutic doses of lithium, which required augmentation with both valproic acid and antipsychotic agents. These medications were poorly tolerated, causing weight gain, alopecia, hirsutism, mild oral tardive dyskinesia, and parkinsonism, both with standard antipsychotics and with olanzapine and risperidone. ECT had been minimally effective.

At admission Ms. A began treatment with quetiapine, which was titrated to 75 mg t.i.d., while she continued maintenance treatment with valproic acid, lithium carbonate, and 6 mg/day of trifluoperazine. Her manic symptoms decreased rapidly with minimal sedation. After discharge she was unable to immediately follow up with outpatient treatment and was readmitted 10 days later with an exacerbation of mania. Her quetiapine dose was increased to 150 mg b.i.d. and 200 mg at bedtime over 4 days. The trifluoperazine and valproate doses were decreased to 4 mg and 1500 mg at bedtime, respectively, to minimize sedation and sialorrhea. Ms. A was discharged after 8 days of hospitalization with full remission of her manic and psychotic symptoms. Over the next 6 months her doses of trifluoperazine and valproic acid were tapered off and discontinued. Her quetiapine dose was adjusted to 200 mg in the morning and 400 mg at bedtime, resulting in weight loss and a decrease in sedation. She has remained clinically stable with combined lithium and quetiapine therapy.

This case suggests that quetiapine can be safe and effective in the treatment of the manic and psychotic symptoms of bipolar disorder. Further clinical trials are needed to confirm its value in the treatment of affective disorders.

Tohen M, Zarate CA Jr: Antipsychotic agents and bipolar disorder. J Clin Psychiatry 1998; 59(suppl 1):38–49
 
Barnes TR, McPhillips MA: Novel antipsychotics, extrapyramidal side effects and tardive dyskinesia. Int Clin Psychopharmacol 1998; 13(suppl 3):S49–S57
 
Segal J, Berk M, Brook S: Risperidone compared with both lithium and haloperidol in mania: a double-blind randomized controlled trial. Clin Neuropharmacol  1998; 21:176–180
[PubMed]
 
McElroy SL, Frye M, Denicoff K, Altshuler L, Nolen W, Kupka R, Suppes T, Keck PE Jr, Leverich GS, Kmetz GF, Post RM: Olanzapine in treatment-resistant bipolar disorder. J Affect Disord  1998; 49:119–122
[PubMed]
[CrossRef]
 
McElroy SL, Dessain EC, Pope HG Jr, Cole JO, Keck PE Jr, Frankenberg FR, Aizley HG, O’Brien S: Clozapine in the treatment of psychotic mood disorders, schizoaffective disorder, and schizophrenia. J Clin Psychiatry  1991; 52:411–414
[PubMed]
 
Borison RL, Arvanitis LA, Miller BG: ICI 204,636, an atypical antipsychotic: efficacy and safety in a multicenter, placebo-controlled trial in patients with schizophrenia. US Seroquel Study Group. J Clin Psychopharmacol  1996; 16:158–169
[PubMed]
[CrossRef]
 
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References

Tohen M, Zarate CA Jr: Antipsychotic agents and bipolar disorder. J Clin Psychiatry 1998; 59(suppl 1):38–49
 
Barnes TR, McPhillips MA: Novel antipsychotics, extrapyramidal side effects and tardive dyskinesia. Int Clin Psychopharmacol 1998; 13(suppl 3):S49–S57
 
Segal J, Berk M, Brook S: Risperidone compared with both lithium and haloperidol in mania: a double-blind randomized controlled trial. Clin Neuropharmacol  1998; 21:176–180
[PubMed]
 
McElroy SL, Frye M, Denicoff K, Altshuler L, Nolen W, Kupka R, Suppes T, Keck PE Jr, Leverich GS, Kmetz GF, Post RM: Olanzapine in treatment-resistant bipolar disorder. J Affect Disord  1998; 49:119–122
[PubMed]
[CrossRef]
 
McElroy SL, Dessain EC, Pope HG Jr, Cole JO, Keck PE Jr, Frankenberg FR, Aizley HG, O’Brien S: Clozapine in the treatment of psychotic mood disorders, schizoaffective disorder, and schizophrenia. J Clin Psychiatry  1991; 52:411–414
[PubMed]
 
Borison RL, Arvanitis LA, Miller BG: ICI 204,636, an atypical antipsychotic: efficacy and safety in a multicenter, placebo-controlled trial in patients with schizophrenia. US Seroquel Study Group. J Clin Psychopharmacol  1996; 16:158–169
[PubMed]
[CrossRef]
 
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