This volume brings together some of the most eminent clinical researchers in this field. It is a transatlantic monograph that covers most areas in the treatment of depression, including the depressive phase of bipolar disorder, as well as phototherapy and ECT. The information covered in this monograph, although abundantly available as supplements to several psychiatric journals, is of better quality here, with superb scholarship and incisive logic. There is also a thoughtful chapter on "The Role of the Patient in Treatment Decisions," a topic rarely discussed in the psychiatric literature. Beyond these substantive content areas, a distinctive feature of this monograph is its emphasis on how to think about treatment strategies in mood disorders. For this reason, I found the title of the book to be somewhat misleading, because it suggests a clinical focus—when it is largely epistemological.