The hallmark of psychoanalysis, and really all psychotherapy, is the attempt to fathom and, if possible, to ameliorate a patient’s subjective reality. Psychotherapy entails such entities as self, person, meaning, values, and free will—all of which may be even less reducible to biology than the vaguer notion of "mind." Psychotherapy presupposes a freedom of subjective will that exists even in the context of great adversity. Psychotropic medication and other somatic treatments are necessary because there are obvious (and sometimes not-so-obvious) limits to freedom of will. The interplay of the two approaches, subjective and objective, touch on paradox and the limits of our understanding, but they are complementary and not mutually exclusive. If this argument turns out to be wrong, and biology does someday fully explain subjectivity, then traditional notions of autonomy and individual freedom will be discounted, psychotherapy will become superfluous, and our views of human beings, self, and other will alter in ways that are difficult to foresee.