To the Editor: We report a case of priapism after the administration of olanzapine in a patient who on two previous occasions had had priapism that was associated with clozapine treatment. The first case of priapism associated with atypical antipsychotics was reported in 1992 and involved clozapine (1). Subsequently, at least five other reports of clozapine-associated priapism have appeared in the literature. The first reported cases of priapism after the administration of olanzapine were published in 1998 (2, 3). Many medications have been associated with priapism, which is thought to be related to α-adrenergic blockade. Olanzapine has a pharmacological profile similar to that of clozapine, with a high affinity for dopamine D1, D2, and D4, serotonin (5-HT) 5-HT2A, 5-HT2C, and 5-HT3, muscarinic, α1-adrenergic, and histamine H1 receptors. This medication is increasingly used because of its proven antipsychotic activity and favorable side effect profile.