I sometimes facetiously remark that it has been a blessing or a curse as a practitioner to have lived through two "drug epidemics" (heroin in the 1960s and cocaine in the 1980s). In either case, persisting up to the present time in office practice, where now most of my patients are dependent on alcohol or proprietary drugs, I have had the opportunity to work with a wide variety of patients with substance use disorders and garner much knowledge and understanding about the causes and consequences of substance use disorders and their treatment. Although I suspect Dr. Senay has a few more years on me in this field and embraces a different perspective than mine, it is reassuring that, independent of each other (I have frequently cited his research but have never met him), we come to similar conclusions about the practical and clinical need for understanding and treating patients with substance use disorders. There have been too many myths and controversies in addiction medicine/psychiatry, and Dr. Senay cuts through most of them with even-handed, sage observations and helpful clinical guidelines regarding understanding and working with all of the substances that cause drug dependency. Although Dr. Senay covers this ground in less than 250 pages, this master clinician’s fund of knowledge is encyclopedic, and he presents his extensive clinical experience and practical knowledge in an engageable and stimulating way.