The early psychiatric symptoms of Creutzfeldt-Jakob disease previously described in the literature include depression, affective lability, sleep disturbance, personality change, and memory impairment (1–3). Psychosis, although infrequent, may be present; auditory hallucinations and delusional ideas coexist with fluctuations in the level of consciousness (2). The diagnosis of Creutzfeldt-Jakob disease is aided by an EEG. A characteristic pattern of repetitive sharp waves or slow spikes followed by synchronous triphasic sharp waves is seen in 70% of the patients (2). A CT scan and magnetic resonance imaging usually show cerebral atrophy (2), and a CSF analysis for detection of protein 14-3-3 can confirm the clinical and encephalographic diagnosis. There has been an increase in the prevalence of Creutzfeldt-Jakob disease in European countries in recent decades (1). Our case report highlights the importance of considering Creutzfeldt-Jakob disease in the differential diagnosis of delirium once subtle neurologic deficits are identified in conjunction with psychiatric disturbances.