An important function of the human brain is learning and memory. Environmental demands on memory vary greatly. In some instances, we are required to keep information "online" for active use for several seconds, whereas in other instances, we are required to store information for retrieval days, weeks, or even years later. Take, for example, the long-term memory of temporally unique events, commonly called episodic memory. This form of memory is characterized by having a unique context associated with a learning episode. Episodic memory can be seen as a specialized form of more general memory functions that permits the storage and retrieval of facts and bits of information. However, episodic memory differs in that it requires access to the context and personal participation in an event that mark it as a specific episode in memory. A set of interdependent brain regions is clearly critical to the successful learning, storage, and retrieval of episodic memories.