The second point to reiterate is that while there were some marginal differences between the self-report ratings and the informant ratings, as determined by standard statistical tests of significance (i.e., t tests), the magnitude of these differences, as determined by the effect size (i.e., Cohen’s d), was not clinically meaningful. Dr. Reich did not address this issue in his reinterpretation of the results from our report. This point is best exemplified from the results of an earlier study conducted by our group (2), which examined the differences between acutely ill and fully recovered depressed patients. Although the acutely depressed patients had significantly higher neuroticism and significantly lower extraversion scores than the recovered patients, scores for both patient groups remained in the clinically significant range. Thus, the clinical interpretation for the test scores of the recovered and nonrecovered patients would not change. Finally, it is instructive to note that of the four studies cited by Dr. Reich in support of the position that depressed or anxious mood influences personality traits, not one of them calculated effect sizes or otherwise ascertained the clinical significance of statistical differences.