The charts of 20 patients (12 men and eight women) with comorbid bipolar disorder and alcohol abuse/dependence who had been prescribed valproate were reviewed, and results of the following laboratory tests were evaluated: alkaline phosphatase, alanine aminotransferase, lactate dehydrogenase, γ-glutamyltransferase, aspartate aminotransferase, total bilirubin, WBC count, and platelet count. All patients had baseline test results and at least one set of follow-up laboratory test results for comparison. The patients were followed for an average of 5 months. Their average age was 38.7 years (SD=8.5). The patients had an average valproate level of 69.9 mg/liter (SD=15.8), with an average daily dose of 1562.5 mg (SD=499.1).