Seven papers in this issue of the Journal illustrate the importance of psychiatric research for clinical practice. Two studies, one by Wahlbeck et al. on the use of clozapine and the other a long-term follow-up of depressed patients by Mueller et al., examined treatment effects in large groups of patients. Two conclusive practice-shaping conclusions emerge. First, clozapine is definitively more effective in reducing schizophrenic symptoms than are typical neuroleptics. Second, continued antidepressant treatment is definitively associated with prevention of recurrence and relapse. These two papers will influence the treatment of patients with schizophrenia and major depression and result in improved patient care. Three other papers will stimulate rethinking of current psychiatric theory and practice. Nelson et al. report that a tricyclic and a selective serotonin reuptake inhibitor are equally effective in treating severely depressed patients with ischemic heart disease, DeRubeis et al. report that cognitive behavior therapy is as effective as antidepressant treatment for the treatment of severely depressed patients, and the data of Meyer et al. call into question the relevance of serotonin dysfunction in nonsuicidal depressed patients. These three papers illustrate the vitality of the psychiatric research enterprise: its ability to reexamine basic tenets and revise practice accordingly. In the sixth paper, Calabrese et al. suggest the effectiveness of lamotrigine, extending the range of available medications for the treatment of bipolar disorder and calling for more research into this new drug. The seventh paper, by Marcus et al., indicates that psychiatrists do not use research-derived information in their daily work, as indicated by the substantial number of Medicaid patients with bipolar disorder who do not receive recommended therapeutic plasma drug monitoring during their maintenance treatment.