To the Editor: Ralph E. Hoffman, M.D., and Thomas H. McGlashan, M.D. (1), propose a computer model of a neural network in which excessive synaptic pruning causes hallucinated speech. Several aspects of this article require comment. Drs. Hoffman and McGlashan state that they "assume" that pruning is "Darwinian" and cite Edelman’s theories. However, neuronal competition for trophic factors has been demonstrated by 50 years of research. It is a disservice to the pioneering contributions of Hamburger, Purves, Cowan, Levi-Montalcini (who received the Nobel Prize), and many others to ignore this body of work. Drs. Hoffman and McGlashan also fail to cite other directly relevant literature. For example, they point out that the ontogenetic curves for cortical metabolic rate and synaptic density are parallel, but they do not note that this relation was predicted in my first article on synaptic elimination and schizophrenia (2). I later documented this parallel relation statistically, using PET data, in collaboration with Thode, Chugani, and March (3).