The book is divided into two parts. Part I is titled “Classes of Psychiatric Treatments: Animal and Human Pharmacology.” This part includes 34 chapters, which systematically review psychotropic medications within each drug class, focusing whole chapters on a single drug. This part also features new chapters on recently introduced medications, including desvenlafaxine, pregablin, paliperidone, lurasidone, asenapine, and iloperidone, as well as cognitive enhancers, and updated chapters on other psychotropic medications. Overall, the chapters are well done and uniformly good; most of them provide concise description and evidence for each contention that is discussed. It is easy to find specific drug information given that there are specific chapters for each drug and racemate. A medication-specific chapter presents key information on preclinical and clinical pharmacology and discusses general issues regarding the mechanisms of drug action, pharmacokinetics, pharmacodynamics, approved indications, routes of administration, dosage schedules, common side effects, drug interactions, and other prescribing factors. This part contains good clinical information on psychotropic medications, but it would be more efficient to discuss the similarities of medications in a section on each class of psychotropic medications and then highlight clinically significant differences, the common side effects with information on the clinically significant differences for each medication. For example, for selective serotonin reuptake inhibitors (SSRIs), discussion could include which one carries the greatest risk of insomnia, bleeding, QTc prolongation, or antiplatelet effect or a greater propensity for weight gain and sexual side effects, even though weight gain and sexual side effects are possible with all SSRIs. If the textbook were organized differently, this comparison could more easily be made.