Acute response of catatonia to lorazepam appears to be independent of manner of administration (R15601CHDDCHBA–R15601CHDBIEHG). Rosebush et al. (R15601CHDDCHBA) contended that response to lorazepam in their patients, four of whom were already receiving standing oral doses of benzodiazepines, was due to increased blood levels. Parenteral lorazepam, which produces rapid increases in plasma levels more reliably than other benzodiazepines, might be effective in nonresponders to oral benzodiazepines. We report a series of elderly patients with psychotic depression and catatonia (six men and one woman with a mean age of 73), treated with intramuscular lorazepam alone. All were referred to our geriatric psychiatry inpatient service for involuntary ECT. All had failed to respond to antidepressants with antipsychotics. Six had mutism, three negativism, three withdrawal, and one refusal to eat. A single dose of intramuscular lorazepam (2 mg in six patients, 0.5 mg in one) was given. Relief of catatonia, permitting meaningful conversation, occurred in six of seven patients within 2 hours. Responders were maintained on a regimen of oral lorazepam. Four went on to respond to ECT given on a voluntary basis; one responded to a course of oral risperidone, which his catatonia had previously prevented him from complying with; and one enjoyed a full remission of depression without further intervention. Response was dramatic in our responders.