First, they state that although we used the maximum recommended dose of fluoxetine, we failed to use the maximum recommended dose of phenelzine, thus biasing our results in favor of fluoxetine. Although many years have passed since this study was conceived and started, the authors’ assertion that the maximum dose of phenelzine for OCD is known is unfortunately not accurate. They cite no systematic study demonstrating that 90 mg of phenelzine is better than 60 mg for OCD; to our knowledge, no such study exists. In addition, we often use doses higher than 80 mg for fluoxetine. In a study such as ours, the prudent investigator has to make certain decisions about dose and length of trial without the availability of perfect information.