Embarking on a journey into the wilderness of prevention research for mental disorders is not such a solitary, limiting venture as it was 10 years ago. Pioneers in prevention research now have a credible resource book, Reducing Risks for Mental Disorders. The book, written by the Institute of Medicine's Committee on Prevention of Mental Illness, comprises the contributions of highly respected research professionals who have made significant contributions to the treatment of major mental illnesses. This collaborative work by an interdisciplinary committee has resulted in a book that is well organized, highly informative, and easy to read. After focusing for decades on treatment research for mental illness, a science of preventive interventions has come of age. Initiation of a science of prevention research in psychiatry depends on the provision of funds and setting of priorities by the National Institute of Mental Health, National Institute on Drug Abuse, National Institute on Alcohol and Alcohol Abuse, and other granting agencies. Such funds and priorities will be needed to develop an infrastructure for identifying, developing, analyzing, and evaluating prevention models and programs in the next decade that might reduce the incidence and prevalence of mental illness.