TO THE EDITOR: A number of case reports have suggested that clozapine, with its broad pharmacological activity, may be useful in the treatment of psychotic depression. Parsa et al. (1) found clozapine to be useful and well tolerated in a patient with Parkinson's disease for whom the use of a standard neuroleptic had been problematic. Likewise, Dassa et al. (2) found that clozapine was effective in treating psychotic depression in a 40-year-old patient for whom conventional treatments, including ECT, had been ineffective. Olanzapine shows many of the pharmacological properties of clozapine but has a better side effect profile (3). We present a case that suggests that, like clozapine, olanzapine monotherapy may be an effective treatment for psychotic depression.