“Ms. B,” a 29-year-old woman, gravida 1, para 0, with two previous depressive episodes, presented at 18 weeks gestation with depressive symptoms including low mood, anhedonia, hypersomnia, low energy, and guilt. A diagnosis of recurrent major depressive disorder was confirmed using the Structured Clinical Interview for DSM-IV. Ms. B had discontinued sertraline (100 mg) 8 months earlier for pregnancy planning. Computer-assisted CBT comprised eight therapy sessions over 6 weeks with a clinical psychologist (3.75 hours of direct contact), with between-session web-based modules (“Good Days Ahead”; Empower Interactive, San Francisco) (5). Therapy sessions included collaborative agenda setting, reviewing skill implementation, and previewing web-based content. Web-based modules included video vignettes, psychoeducational content, and exercises (e.g., automatic thought records). Ms. B had good adherence and experienced remission. She exhibited a 94% reduction in her Hamilton Depression Rating Scale scores from the pretreatment assessment (score, 17) to the posttreatment assessment (score, 1). Her Beck Depression Inventory scores (pretreatment score, 26; posttreatment score, 2) and Edinburgh Postnatal Depression Scale scores (pretreatment score, 17; posttreatment score, 5) also decreased markedly. Her Global Assessment of Functioning score improved from 55 to 90. Subjective report indicated that Ms. B found computer-assisted CBT acceptable, and she expressed satisfaction in avoiding antidepressant use during pregnancy.