A pooled analysis based on a random-effects model and using odds ratio as an association measure is depicted in Figure 1. The number of individuals with metabolic syndrome was 705 among bipolar patients and 890 among schizophrenia patients. The pooled odds ratio (bipolar compared with schizophrenia) was 1.01 (95% CI=0.82–1.24; p=0.93), with low heterogeneity across the studies (I2=31%; p=0.15). In addition, a subanalysis based on four studies reporting significantly higher rates of antipsychotic prescriptions in people with schizophrenia revealed a similar chance of metabolic syndrome for individuals with bipolar disorder (odds ratio=0.98, 95% CI=0.70–1.38; p=0.91). Further subanalyses did not reveal any statistical difference. We believe these findings may well complement those reported by Vancampfort et al. (1). Individuals with bipolar disorder and schizophrenia have comparable chances of having metabolic syndrome. Despite important differences in clinical features, these individuals may actually share a number of health behaviors, including poor physical activity, unhealthy diet, excessive alcohol intake, and smoking habits. Future research should assess the relative contribution to metabolic syndrome not only of different psychiatric diagnoses, but also of components such as genetics, antipsychotic medication use, lifestyle, and health behaviors.