OBJECTIVE: The authors' goal was to determine whether either of two 5-
HT2A receptor polymorphisms, 102-T/C and 452-His/Tyr, are associated with
clozapine response. METHOD: Brief Psychiatric Rating Scale (BPRS) ratings
were obtained in 70 patients with schizophrenia or schizoaffective disorder
to determine their response to clozapine compared with a typical
neuroleptic. Patients were genotyped with the polymerase chain reaction and
restriction fragment length polymorphism analysis. RESULTS: Neither 102-T/C
nor 452-His/Tyr was associated with clozapine response. There were no
significant differences in BPRS scores among patients with different 5-HT2A
genotypes at week 10 of clozapine administration. CONCLUSIONS: Allelic
variation in the 5-HT2A gene is not associated with individual differences
in clozapine response.
Abstract Teaser