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The American Journal of Psychiatry, VOL. 153, No. 3

REGULAR ARTICLES | March 01, 1996

Change in thyroid hormone levels following response to cognitive therapy for major depression

Am J Psychiatry 1996;153:411-413.

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Abstract

OBJECTIVE: Various somatic antidepressant treatments of depression are associated with substantial but limited decreases in T4 levels. This study examined changes in patients' thyroid hormone levels during a period of cognitive behavior therapy. METHOD: Thyroid hormone levels of 30 patients with major depressive disorder were measured before and after they received 20 weekly sessions of cognitive behavior therapy. RESULTS: There were significant decreases in measures of T4 in the 17 responders to cognitive behavior therapy and increases in the 13 nonresponders. CONCLUSIONS: Cognitive behavior therapy has an effect on the thyroid axis similar to that of somatic antidepressant treatments.

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