OBJECTIVE: The purpose of the study was to ascertain whether
phototherapy light visors provide an effective treatment for seasonal
affective disorder. Previous studies have demonstrated a moderate response
rate but have failed to find any difference in efficacy between light
intensities. METHOD: Subjects were randomly assigned to receive, over a
2-week treatment period, 30 minutes of morning phototherapy with a light
visor that emitted either a dim (30-lux) red light or a bright (600-lux)
white light. Raters were blind to treatment, and patients were unaware of
the alternatives. Response was assessed by using the structured 21-item
Hamilton Depression Rating Scale, with an eight-item addendum for atypical
depressive symptoms. Fifty-seven patients were enrolled across two sites.
RESULTS: Patients assigned to the different visors had similar baseline
depression scores and similar expectations of outcome. Hamilton depression
scale scores declined by 34.6% for subjects given bright white light and by
40.9% for subjects given dim red light. Scores for atypical depressive
symptoms fell by 44.1% for patients assigned the bright white light visors
and by 49.0% for patients assigned the dim red light visors. Altogether,
39.3% of the patients who received red light and 41.4% of the patients who
received bright white light showed a full clinical response. CONCLUSIONS:
There were no significant differences in therapeutic response between
patients who were treated with red or white light. The results of this
study suggest that the phototherapy light visor may function as an
elaborate placebo. Alternative explanations, however, are considered.
Abstract Teaser