OBJECTIVE: The authors examined the efficacy of methylphenidate in the
treatment of depression in a group of older, medically ill patients.
METHOD: Sixteen patients underwent an 8-day double-blind, randomized,
placebo-controlled crossover trial; 13 completed the trial. RESULTS:
Statistically and clinically significant treatment responses were found.
CONCLUSIONS: These results support the use of methylphenidate in older,
medically ill patients in whom rapid resolution of depressive symptoms is